Controversial results have been reported about the association of calcium, magnesium, and phosphorus and stroke risk, but none in China. To investigate the association between dietary calcium, magnesium, phosphorus, and stroke incidence in Chinese adults, we collected data from the China Health and Nutrition Survey (CHNS) from 2004 to 2011, including 6411 participants aged 45–79 years and free of stroke at baseline. Diet was assessed by interviews combining 3-d 24-h food recalls and household food inventory weighing at each survey round. The stroke incident was identified based on the validated self-report. Multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). For 32,024 person-years of follow-up, 179 stroke cases were documented. After adjustment for major lifestyle and dietary risk factors, calcium intake was positively associated with reduced stroke risk, and the HR of stroke comparing extreme quartiles was 0.53 (95% CI 0.29–0.96, Ppattern = 0.03). In further stratified analyses, significant heterogeneity across sex strata was found (Pcommunication = 0.03). Dietary calcium intake among men was more inversely related to stroke, with HRs being 0.33 (95% CI 0.15–0.76, P trend = 0.02), compared to 1.24 (95% CI 0.46–3.35, Ptrend = 0.89) among women. However, no significant association between stroke and magnesium or phosphorus was revealed. Our findings suggest that higher dietary calcium intake was associated with a lower risk of stroke in Chinese adults, particularly in men.
As the a beneficial cerebrovascular disease, coronary attack is probably the top cause for demise in build and you may development countries. Good 10% overall yearly passing internationally are projected to-be attributable to they step one . Even the coronary arrest survivors, as much as 15–30% is actually forever disabled dos , which leads to as much as 113 mil impairment-modified lives age missing step three . China has got the mobifriends recenzja high estimated lifetime risk of stroke around the world (39.3%) according to the 2016 around the world burden of situation (GBD) regional analysis cuatro . Seem to, coronary attack has been a critical societal health issue to own Asia within the facing the elevated aging society. For this reason, pinpointing brand new convertible exposure facts was pressing toward prevention and the advance out-of existence top-notch heart attack clients and also the cures away from enormous socio-monetary load.
Diet calcium supplements, magnesium, and you can phosphorus intakes and you may danger of coronary attack into the Chinese grownups
Whilst particular etiology is not totally elucidated, coronary attack may be thought a sickness connected with hereditary and you can environment risk activities (particularly slimming down) or perhaps the interplay of those facts. Detailed facts means that dieting improvement are extremely advantageous to prevent the brand new start of coronary attack 5,6,7 . A near relationship can be obtained between calcium, magnesium, phosphorus, and you may vascular shelter, which are experienced important wellness effects getting vascular ailment simply because they can also be regulate vascular calcification and you may endothelial breakdown 8,nine . To date, multiple research has checked-out the partnership anywhere between such nutrients consumption and you can coronary attack risk ten,eleven,a dozen , nevertheless the email address details are contradictory. Eg, lookup regarding European people presented magnesium intake, not calcium try somewhat connected with less danger of stroke eleven . Conversely, in the us, calcium supplements intake, in place of magnesium, leads to ong guys, magnesium intake are inversely of the heart attack 12 . Additionally, each one of these scientific studies were presented inside western communities with high intakes of those minerals thirteen,fourteen . not, to the degree, little known in regards to the connection out of dieting calcium, magnesium, and you may phosphorus consumption having coronary arrest chance on the Chinese inhabitants. The average fat reduction consumption ones micronutrients among Chinese someone taking predominantly plant-built diet was considered to be below that of Europeans and you may People in the us with so much more whole milk and meat affairs fifteen . Within this framework, a large-size potential study throughout the Chinese people to complement new association’s evidence is admittedly needed. We, ergo, put research on China Health and Nourishment Questionnaire (CHNS) to check on the partnership between fat reduction calcium supplements, magnesium, and you will phosphorus consumption and you can further frequency from heart attack from inside the Chinese adults.